P35: Neuroprotective Effect of Noscapine on Cerebral Oxygen-Glucose Deprivation Injury

نویسندگان

  • Ebrahimi , Soltan-Ahmad Department of Pharmacology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Rahbar-Roshandel , Nahid Department of Pharmacology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Vahabzadeh , Gelareh Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
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p35: neuroprotective effect of noscapine on cerebral oxygen-glucose deprivation injury

the present study aims to investigate the effect of noscapine (0.5-2.5 µm), an alkaloid from the opium poppy, on primary murine fetal cortical neurons exposed to oxygen–glucose deprivation (ogd), an in vitro model of ischemia. cells were transferred to glucose-free dmem (dulbecco's modified eagle medium) and were exposed to hypoxia in a small anaerobic chamber. cell viability and nitric ox...

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Neuroprotective effect of noscapine on cerebral oxygen-glucose deprivation injury.

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The Effect of Noscapine on Oxygen-Glucose Deprivation on Primary Murine Cortical Neurons in High Glucose Condition

AbstractIn the present work we set out to investigate the neuroprotective effects of noscapine (0.5-2 µM) in presence of D-glucose on primary murine foetal cortical neurons after oxygen–glucose deprivation/24 hrs recovery. Cell viability, nitric oxide production and intracellular calcium ([ca2+]i) levels were evaluated by MTT assay, the modified Griess method and Fura-2 respectively. 25 and 100...

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The Effect of Noscapine on Oxygen-Glucose Deprivation on Primary Murine Cortical Neurons in High Glucose Condition

AbstractIn the present work we set out to investigate the neuroprotective effects of noscapine (0.5-2 µM) in presence of D-glucose on primary murine foetal cortical neurons after oxygen–glucose deprivation/24 hrs recovery. Cell viability, nitric oxide production and intracellular calcium ([ca2+]i) levels were evaluated by MTT assay, the modified Griess method and Fura-2 respectively. 25 and 100...

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Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia.

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The Effect of Noscapine on Oxygen-Glucose Deprivation on Primary Murine Cortical Neurons in High Glucose Condition

In the present work we set out to investigate the neuroprotective effects of noscapine (0.5-2 µM) in presence of D-glucose on primary murine foetal cortical neurons after oxygen-glucose deprivation/24 h. recovery. Cell viability, nitric oxide production and intracellular calcium ((ca(2+))i) levels were evaluated by MTT assay, the modified Griess method and Fura-2 respectively. 25 and 100 mM D-g...

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عنوان ژورنال

دوره 2  شماره 4

صفحات  85- 85

تاریخ انتشار 2014-12

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